Whether you're here for a Mayo Clinic visit or a spontaneous weekend getaway, Rochester, Minnesota offers more than meets the eye. In just 48 hours, you can explore a vibrant city packed with local eats, live music, tasty brews and public art; unwind in scenic parks and trails; and discover unique attractions that blend culture, history, and Midwestern charm. This two-day guide is your key to experiencing Rochester at its fullest, whatever your speed.

Day 1: Thursday

Morning: Bike, Hike or Walk on Rochester’s Trails

Rochester has more than 85 miles of paved, interconnected walking and biking trails. Start your morning with a walk and get a great introduction to the city, all while enjoying the fresh air and scenic views. Not sure where to begin? Cascade Lake Park has paved trails along newly landscaped areas, a nature playground, beach and lake, and more.

Afternoon: Tour the Rochester Art Center

Continue your day with a visit to the Rochester Art Center, a contemporary arts hub offering world-class exhibitions by local, regional and nationally working artists. After browsing the art center, walk outdoors or through the climate-controlled skyway for some shopping at the Galleria at University Square, where there are several great lunch options, including Salad Brothers, R’s Pizza, and Chester’s.

Evening: Thursdays Downtown

This summer, Every Thursday through August 14, 2025 (except July 3), downtown Rochester comes alive with Thursdays Downtown. This free, family-friendly community event showcases the best of the city with local food and beverage vendors, artisans, and live music performances on two stages. Soak in the festive atmosphere with the Rochester community while enjoying local cuisine and shopping for unique one-of-a-kind finds.

Day 2: Friday

Rochester Trolley & Tour Co. | AB-Photography.US

Morning: Take a Trolley Tour of Rochester

After fueling up at one of many cozy brunch spots in Rochester, hop on board the Rochester Trolley & Tour Co.’s Queen City History Tour. The tour takes passengers on a fascinating journey through the city’s rich past. From historic landmarks to the story of Mayo Clinic’s roots, the tour is perfect for history lovers, including locals and visitors alike.

Afternoon: Quarry Hill Nature Center

Quarry Hill is a 329-acre historic park with a variety of walking and hiking trails and a Nature Center with more than 35 species of live animals. The park is free to visit, and although it’s just minutes away from downtown Rochester, it feels like a peaceful, secluded nature escape.

Evening: Downtown Dinner & Drinks

Conclude your visit with a relaxing evening downtown at one of the many locally loved restaurants. Whether you’re craving upscale dining at Marrow, global flavors at Lumi, or a laid-back patio meal at Bebap, there’s something for every taste. Afterward, slip into Bitter & Pour, a hidden speakeasy known for its masterfully crafted cocktails and national acclaim as one of the top-rated speakeasies in the country. It’s the perfect spot to toast to a memorable 48 hours in Rochester!

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