Getting to Rochester's Mayo Clinic

Rochester is located in southeastern Minnesota, in the heart of the United States’ Upper Midwest region.

Airports Near Mayo Clinic in Rochester, MN

There are two convenient air options when visiting Rochester:

The Rochester International Airport (RST) provides direct flights to Atlanta, Minneapolis, and Chicago, and connecting flights to more than 640 destinations. 

The Minneapolis-St. Paul International Airport (MSP), located 90 miles from Rochester, is another quick and easy option for air service. Daily van shuttle service is available from MSP to Rochester, with shuttle drop-off at a number of Rochester hotels and other locations.


Mayo Clinic patients arriving through Rochester International Airport can find Mayo Clinic, appointment and transportation information related to their medical visit at the Mayo Clinic help desk located in the Main Terminal lobby. Mayo Clinic staffs the help desk from 9:30 a.m. - 6 p.m., Sunday – Thursday, to assist patients.

Sometimes airlines may be able to offer specials discounts for patients traveling to Mayo Clinic and their family members. There is no guarantee that a discount will be available for travel but a quick call to the airline or a travel agent may help save a few dollars.

Drive to Rochester

Approximates driving times to Rochester are: 80 minutes from Minneapolis/St. Paul, Minnesota; three hours from Des Moines, Iowa, and five and a half hours from Chicago, Illinois.

Rail & Bus

Amtrak provides daily train service between Chicago and the Pacific Northwest. The train departs from the Amtrak depot in Winona, located about 45 miles east of Rochester. Daily bus/shuttle is available to and from the train depot on Carefree Shuttle.

Jefferson Bus Lines offers service from Rochester to many cities and it connects to Greyhound in Minneapolis.

Mayo Clinic Travel Resources

Mayo Clinic Concierge Services can assist patients and visitors with questions related to lodging, transportation, local businesses and attractions. They are located in the Mayo Building, Lobby Level
Phone: 507-538-8438; Email:

For a fee – Mayo Clinic patient travel services can assist with flight reservations, changes to existing travel itineraries, hotel reservations, ground transportation,
Phone: 720-956-6055 or 866-551-3392 (toll-free, U.S. & Canada); Email:

If you need more details on how to get to Rochester, MN, use this additional information on airports, driving directions, and more.

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