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Built in 1911 by Dr. Charles H. Mayo, this historic 38-room mansion was home to three generations of the famous family. The 5-story, stone structure now boasts an extensive decorative arts collection, gorgeous gardens, and antique furnishings from French, Spanish, German, and American cultures. General tours are scheduled Wednesdays, Saturdays, and Sundays (March-October), with a seasonal Christmas tour in November and December.