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Built in 1911 by Dr. Charles H. Mayo, this historic 38-room mansion was home to three generations of the famous family. The 5-story, stone structure now boasts an extensive decorative arts collection, gorgeous gardens, and antique furnishings from French, Spanish, German, and American cultures. General tours are scheduled Wednesdays, Thursdays, Saturdays, and Sundays, with a seasonal Christmas tour in November and December.