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Built in 1911 by Dr. Charles H. Mayo, this historic 38-room house was home to three generations of the famous family. The 5-story, stone structure now boasts an extensive decorative arts collection, gorgeous gardens, and antique furnishings from French, Spanish, German, and American cultures. General tours are scheduled Wednesdays, Saturdays, and Sundays (March-July), and adding a Thursday tour August thru October, and seasonal Christmas tours in November until  December 18, 2022. Mayowood closes after the Christmas Season until Spring of 2023.